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KMID : 0358420080510050555
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Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 5 p.555 ~ p.562
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The expression of p57kip2 in normal ovaries and ovarian tumors
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Ann Mi-Jin
Hur Sung-Eun
Kim Bum-Kyeong
Kim Sung-Tae
Kim Ji-Yeon
Lee Sung-Ki
Kim Gyung-Jin
Jang Byoung-Woo
Kim Nam-Hee
Kil Ki-Hyun
Kim Bum-Kyeng
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Abstract
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Objectives: The purpose of this study is to investigate the expression of CDK (Cyclin dependent kinase) inhibitor, p57kip2 in human ovarian corpus luteum, benign and malignant ovarian tumors.
Methods: 46 women undergoing laparoscopic surgery or laparotomy for ovarian tumors were enrolled. Total 46 formalin-fixed, paraffin-embedded sections of corpus luteum, benign and malignant ovarian tumors were stained by immunohistochemistry for expression of p57kip2.
Results: p57kip2 was stained in theca cell of growing follicle but not induced in human corpus luteum. There was the expression of p57kip2 in mature teratoma, immature teratoma and endometrioma but not in epithelial ovarian tumors.
Conclusions: These results showed that p57kip2 expression may be not important in luteinization of the ovary and seemed not to play a role in development of epithelial ovarian tumors. However, it may involve pathogenesis of mature teratoma, immature teratoma and endometrioma.
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KEYWORD
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p57kip2, Lutenization, Teratoma, Ovarian tumor
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